We investigate how cardiac metabolism is altered in heart failure, and use these discoveries to seek new therapeutic interventions.
Heart disease remains the leading cause of death worldwide. Heart failure—the inability of the heart to pump sufficient blood with each heartbeat—is an increasingly prevalent cause of such disease, contributing to one in 9 deaths in the United States. We study how altering the transport of calcium ions into mitochondria, critical for the cardiac heartbeat and metabolism, can be used to treat heart failure. For these studies, we focus on both adult and pediatric forms of this disease, particularly those caused by mitochondrial dysfunction.
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RT @RutterLab: A great way to start the week! We're proud to present our latest paper, the magnum opus of @jordanberg0, published… https://t.co/hBl2xsbpy0
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RT @jordanberg0: It’s really exciting to see our article describing Metaboverse out in its final form. https://t.co/4DNyzkploh A brief thread... 🧵(1/11)
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RT @UWproteindesign: Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medic… https://t.co/jrTOBSISGn